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The management of radioactive sources is a criti- cal process that ensures the safe and responsible handling of radioactive materials throughout their lifecycle. These sources require careful management from production to disposal, such as real-time tracking and radiation monitoring to follow everyone’s safety rules and protect people and the environment. However, these sources present significant global challenges, especially regarding safety, security, and transparency. Current systems face limitations such as fragmented oversight, lack of accountability, and risks of unauthorized access. To address these limitations, this paper proposes a blockchain-based radioactive source lifecycle management system to manage the lifecycle of radioactive sources. Blockchain’s decentralized and tamper-proof ledger secures data throughout the entire lifecycle of radioactive materials. By using smart contracts and access controls, the system ensures that only authorized parties can monitor and verify transactions in real- time, which reduces human error and prevents unauthorized changes to the data. Users can perform key operations such as retrieving source details, transferring ownership, updating source locations, and adding observers to our proposed system. Our experiment in designing and testing a blockchain application has proven the potential for a secure and transparent system that enhances global cooperation in managing radioactive sources. Overall, the proposed system not only addresses current challenges in radioactive source management but also enhances the tracking and monitoring of radioactive materials.